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Hirota, Tomoya; Veenstra-VanderWeele, Jeremy; Hollander, Eric; Kishi, Taro – Journal of Autism and Developmental Disorders, 2014
Electroencephalogram-recorded epileptiform activity is common in children with autism spectrum disorder (ASD), even without clinical seizures. A systematic literature search identified 7 randomized, placebo-controlled trials of antiepileptic drugs (AEDs) in ASD (total n = 171), including three of valproate, and one each of lamotrigine,…
Descriptors: Autism, Pervasive Developmental Disorders, Drug Therapy, Epilepsy
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Esch, Barbara E.; Carr, James E. – Journal of Autism and Developmental Disorders, 2004
Secretin is used in the United States for diagnosis of pancreatic gastrointestinal (GI) dysfunction and disease. Repeated therapeutic use has not been approved. Widespread interest in secretin as a treatment for autism followed media reports of behavioral improvements in an autistic child who received the hormone during a GI diagnostic procedure.…
Descriptors: Autism, Children, Outcomes of Treatment, Clinical Diagnosis
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McDougle, Christopher J.; Kresch, Laura E.; Posey, David J. – Journal of Autism and Developmental Disorders, 2000
Results from two studies indicate the nonselective serotonin reuptake inhibitor (SRI) clomipramine is more efficacious than the relatively selective norepinephrine reuptake inhibitor desipramine and placebo in children with autism. A study of the selective SRI fluvoxamine found it to be significantly better than placebo for reducing repetitive…
Descriptors: Adults, Behavior Disorders, Behavior Problems, Children
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Tuchman, Roberto – Journal of Autism and Developmental Disorders, 2000
The treatment of seizure disorders and EEG epileptiform abnormalities without epilepsy in children with autism spectrum disorders in considered within the context of the relationship epilepsy and epileptiform disorders to language, behavior, and cognition. The use of anticonvulsants to treat epileptiform discharges thought to be producing…
Descriptors: Autism, Children, Drug Therapy, Epilepsy
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Aman, Michael G.; Langworthy, Kristen S. – Journal of Autism and Developmental Disorders, 2000
A review of 41 studies on pharmacological treatments for children with autism and pervasive personality disorder not otherwise specified, found empirical evidence for significant reductions in hyperactive symptoms was strongest for the antipsychotics, psychostimulants, and naltrexone. A theoretical model is proposed for using attentional…
Descriptors: Attention Deficit Disorders, Attention Span, Children, Drug Therapy